IVF using ICSI Intercytoplasmic Sperm Injection showing needle penetrating egg and inserting sperm into egg under in a microscope image with a grey hue

Intracytoplasmic sperm injection otherwise known as ICSI is performed as part of the in vitro fertilization (IVF) procedure. It is a process in which an embryologist injects a single sperm into the cytoplasm of the egg.

ICSI was first introduced in 1991 at the Free University of Brussels, Belgium. Its initial indication was poor sperm quality or low fertilization rates during previous IVF cycles that used “conventional” IVF.

Over the years, its use has been extended to the point where ICSI cycles represent between 70% and 100% of all IVF cycles.